R. Michael Roberts Research Group at the University of Missouri

Roberts Lab Publications

Most recent (selected from over 342 peer-reviewed publications)

Karvas, R.M., McInturf, S., Zhou, J., Ezashi, T., Schust, D.J., Roberts, R.M., and Schulz, L.C. (2020). Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast. Molecular Human Reproduction. 26(6): 425-440. PMID: 32359161

Mao, J., Ashish, J., Denslow, N.D., Nouri, MZ., Chen, S., Wang, T., Zhu, N., Koh, J., Sarma, S.J., Sumner, B.W., Lei, Z., Sumner, L.W., Bivens, N.J., Roberts, R.M., Tuteja, G., and Rosenfeld, C.S. (2020). Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta-brain axis. Proceedings of the National Academy of Sciences. 117(9): 4642-4652. PMID: 32071231

West, R.C., Ming, H., Logsdon, D.M., Sun, J., Rajput, S.K., Kile, R.A., Schoolcraft, W.B., Roberts, R.M., Krisher, R.L., Jiang, Z., and Yuan, Y. (2019). Dynamics of trophoblast differentiation in peri-implantation-stage human embryos. Proceedings of the National Academy of Sciences. 116(45): 22635-22644. PMID: 31636193

Yuan, Y., Park, J., Tian, Y., Choi, J., Pasquariello, R., Alexenko, A.P., Dai, A., Behura, S.K., Roberts, R.M., and Ezashi, T. (2019). A six-inhibitor culture medium for improved naïve-type pluripotency of porcine pluripotent stem cells. Cell Death Discovery. 5, Article number: 104.
PMID: 31240131

Sheridan, M.A., Yang, Y., Jain, A., Lyons, A.S., Yang, P., Brahmasani, S.R., Dai, A., Tian, Y., Ellersieck, M.R., Tuteja, G., Schust, D.J., Schulz, L.C., Ezashi, T., and Roberts, R.M. (2019). Early onset preeclampsia in a model for human placental trophoblast. Proceedings of the National Academy of Sciences. 116(10): 4336-4345. PMID: 30787190

Karvas, R.M., Yang, Y., Ezashi, T., Schust, D.J., Roberts, R.M., Schulz, L.C. (2018). ITGA1 is upregulated in response to oxygen over time in a BMP4 model of trophoblast. Molecular Reproduction & Development. 85(8-9): 738-739. PMID: 30076663

Sheridan, M.A., Balaraman, V., Schust, D.J., Ezashi, T. Roberts, R.M., Franz, A.W.E. (2018). African and Asian strains of Zika virus differ in their ability to infect and lyse primitive human placental trophoblast. Public Library of Science. 13(7): e0200086. PMID: 29985932

Roberts, R.M., Ezashi, T., Sheridan, M.A., Yang, Y. (2018). Specification of trophoblast from embryonic stem cells exposed to BMP4. Biology of Reproduction. 99: 212-224. PMID: 29579154

Bayer, A., Lennemann, N.J., Ouyang, Y., Sadovsky, E., Sheridan, M.A., Roberts, R.M., Coyne, C.B., Sadovsky, Y. (2018). Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling. Placenta. 61: 33-38. PMID: 29277269

Jain, A., Ezashi, T., Roberts, R.M., Tuteja, G. (2017). Deciphering transcriptional regulation in human embryonic stem cells specified towards a trophoblast fate. Scientific Reports. 7(1): 17257. PMID: 29222466

Yuan, Y., Spate, L.D., Redel, B.K., Tian, Y., Zhou, J., Prather, R.S., Roberts, R.M. (2017). Quadrupling efficiency in production of genetically modified pigs through improved oocyte maturation. Proceedings of the National Academy of Sciences. 114(29): E5796-E5804.
PMID: 28673989

Sheridan, M.A., Yunusov, D., Balaraman, V., Alexenko, A.P., Yabe, S., Verjovski-Almeida, S., Schust, D.J., Franz, A.W., Sadovsky, Y., Ezashi, T., Roberts, R.M. (2017). Vulnerability of primitive human placental trophoblast to Zika virus. Proceedings of the National Academy of Sciences. 114(9): E1587-E1596. PMID: 28193876

Genovese, N.J., Domeier, T.L., Telugu, B.P., Roberts, R.M. (2017). Enhanced development of skeletal myotubes from porcine induced pluripotent stem cells. Scientific Reports 7(4): 41833. PMID: 28165492

Yunusov, D., Anderson, L., DaSilva, L.F., Wysocka, J., Ezashi, T., Roberts, R.M., Verjovski-Almeida, S. (2016). HIPSTR and thousands of IncRNAs are heterogeneously expressed in human embryos primordial germ cells and stable cell lines. Scientific Reports 6: 32753.
PMID: 27605307.
Corrigendum: Scientific Reports 7: 44632. Figure 5 corrected: March 16, 2017. PMID: 28300214

Roberts, R.M., Yuan, Y., Ezashi, T. (2016). Exploring early differentiation and pluripotency in domestic animals. Reproduction, Fertility and Development 29(1): 101-107. PMID: 28278797

Yuan, Y., Yang, Y., Tian, Y., Park, J., Dai, A., Roberts, R.M., Liu, Y., Han, X. (2016). Efficient long-term cryopreservation of pluripotent stem cells at -80C. Scientific Reports 6: 34476. PMID: 27694817

Roberts, R.M., Green, J.A., Schulz, L.C. (2016). The evolution of the placenta. Reproduction 152: R1-R11. PMID: 27486265

Wang, W., Lee, S.J., Scott, P.A., Lu, X., Emery, D., Liu, Y., Ezashi, T., Roberts, R.M., Ross, J.W., Kaplan, H.J., Dean, D.C. (2016). Two-step reactivation of dormant cones in retinitis pigmentosa. Cell Reports 15(2): 372-385. PMID: 27050517

Yabe, S., Alexenko, A.P., Amita, M., Yang, Y., Schust, D.J., Sadovsky, Y., Ezashi, T., and Roberts, R.M. (2016). Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas. Proceedings of the National Academy of Sciences 113(19): E2598-E2607. PMID: 27051068

Ezashi, T., Yuan, Y., and Roberts, R.M. (2016). Pluripotent stem cells from domesticated mammals. Annu, Rev. Anim. Biosci. 4: 8.1-8.31. PMID: 26566158

Green, M.P., Harvey, A.J., Spate, L.D., Kimura, K., Thompson, J.G., and Roberts, R.M. (2016). The effects of 2,4-dinitrophenol and D-glucose concentration on the development, sex ratio, and interferon-tau (IFNT) production of bovine blastocysts. Mol Reprod Dev. 83(1): 50-60.
PMID: 26465354

Roberts. R.M., Yuan, Y., Genovese, N., and Ezashi, T. (2015). Livestock models for exploiting the promise of pluripotent stem cells. ILAR Journal 56(1): 74-82. PMID: 25991700

Yang, Y., Adachi, K., Sheridan, M.A., Alexenko, A.P., Schust, D.J., Schulz, L.C., Ezashi, T., and Roberts. R.M. (2015). Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. Proceedings of the National Academy of Sciences 112(18): E2337-2346. PMID: 25870291

Warzak, D.A., Johnson, S.A., Ellersieck, M.R., Roberts, R.M., Zhang, X., Ho, S-M, and Rosenfeld, C.S. (2015). Effects of post-weaning diet on metabolic parameters and DNA methylation status of the cryptic promoter in the Avy allele of viable yellow mice. Journal of Nutritional Biochemistry 26(6): 667-674. PMID: 25818200

Roberts. R.M. (2014). Breeding for speed. Science 345(6197): 632. PMID: 25104376

Yang, P., Dai, A., Alexenko, A.P., Liu, Y., Stephens, A.J., Schulz, L.C., Schust, D.J., Roberts, R.M. , and Ezashi, T. (2014). Abnormal oxidative stress responses in fibroblasts from preeclampsia infants. PLOS ONE 9(7): e103110. PMID: 25058409

Lee, K., Kwon, D-N., Ezashi, T., Choi, Y-J., Park, C., Ericsson, A.C., Brown, A.N., Samuel, M.S., Park, K-W., Walters, E.M., Kim, D.Y., Kim, J-H., Franklin, C.L., Murphy, C.N., Roberts, R.M. , Prather, R.S., and Kim, J-H. (2014). Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency. Proceedings of the National Academy of Sciences 111(20): 7260-7265. PMID: 24799706

Roberts, R.M., Loh, K.M., Amita, M., Bernardo, A.S., Adachi, K., Alexenko, A.P., Schust, D.J., Schulz, L.C., Telugu, B P.VL., Ezashi, T., and Pedersen, R.A. (2014). Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be? Reproduction 147(5): D1-D12. PMID: 24518070

Yuan, Y., Lee, K., Park, K-W., Spate, L.D., Prather, R.S., Wells, K.D., and Roberts, R.M. (2014). Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and then generation of cloned embryos. Cell Cycle 13(8) : 1265-1276. PMID: 24621508

Yoshinaga, K., Davies, C., White, K., Caron, K., Golos, T., Fazleabas, A., Paria, B. Mor, G., Paul, S., Ye, X., Dey, S.K., Spencer, T., and
Roberts, R.M. (2014). Interdisciplinary collaborative team for blastocyst implantation research: inception and perspectives. Am. J. Reprod. Immuno. 71: 1-11. PMID: 24286196

Rosenfeld, C.S., Johnson, S.A., Ellersieck, M.R., Roberts, R.M. (2013). Interactions between parents and pups in the monogamous California mouse (Peromyscus californicus). PLOS ONE 8(9): e75725. PMID: 24069441

Williams, S.A., Jasarevic, E., Vandas, G.M., Warzak, D.A., Geary, D.C., Ellersieck, M.R., Roberts, R.M., Rosenfeld, C.S. (2013). Effects of developmental bisphenol A exposure on reproductive-related behaviors in California mice (Peromyscus californicus): A monogamous animal model. PLOS ONE 8(2): e55698. PMID: 23405200

Telugu, B.P., Adachi, K., Schlitt, J.M., Ezashi, T., Schust, D.J., Roberts, R.M., Schulz, L.C. (2013). Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas. Placenta 34: 536-543. PMID: 23631809

Amita, M. Adachi, K, Alexenko A.P., Sinha, S., Schust, D.J., Schulz, L.C., Roberts R.M., Ezashi, T. (2013). Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. PNAS 110(13): 1212-1221. PMID: 23493551

Cibelli, J., Emborg, M., Prockop, D.J., Roberts, R.M., Schatten, G., Rao, M., Harding, J., and Mirochnitchenko, O. (2013). Strategies for improving animal models for regenerative medicine. Cell Stem Cell 12(3) : 271-274. PMID: 23472868

Rosenfeld, C.S., Sieli, P.T., Warzak, D.A., Ellersieck, M.R., Pennington, K.A., and Roberts, R.M. (2013). Maternal exposure to bisphenol A and genistein has minimal effect on Avy/a offspring coat color but favors birth of agouti over nonagouti mice. PNAS 110(2) : 537-542.
PMID: 23267115

Jasarevic, E., Williams, S.A., Vandas, G.M., Ellersieck, M.R., Liao, C., Kannan, K., Roberts, R.M. , Geary, D.C., and Rosenfeld, C.S. (2012). Sex and dose-dependent effects of developmental exposure to bisphenol A on anxiety and spatial learning in deer mice (Peromyscus maniculatus bairdii) offspring. Hormones and Behavior 63: 180-189. PMID: 23051835

Jasarevic, E., Williams, S.A., Roberts, R.M. , Geary, D.C., and Rosenfeld, C.S. (2012). Spatial navigation strategies in Peromyscus: a comparative study. Animal Behaviour 84(5) : 1141-1149. PMID: 23355748

Ezashi, T., Telugu, B.P., and Roberts, R.M. (2012). Induced pluripotent stem cells from pigs and other ungulate species: An alternative to embryonic stem cells? Reproduction in Domestic Animals 47(Suppl. 4) : 92-97. PMID: 22827356

Bermejo-Alvarez, P., Rosenfeld, C.S., and Roberts, R.M. (2012). Effect of maternal obesity on estrous cyclicity, embryo development and blastocyst gene expression in a mouse model. Human Reproduction 27: 3513-3522. PMID: 23001779

Bermejo-Alvarez, P., Roberts, R.M., and Rosenfeld, C.S. (2012). Effect of glucose concentration during in vitro culture of mouse embryos on development to blastocyst, success of embryo transfer, and litter sex ratio. Molecular Reproduction and Development 78(5): 329-36.
PMID: 22461414

Ezashi, T.E., Telugu, B.P., and Roberts, R.M. (2012). Model Systems for Studying Trophoblast Differentiation from Human Pluripotent Stem Cells. Cell & Tissue Research 249: 809-824. PMID: 22427062

Gupta, R., Ezashi, T.E., and Roberts, R.M. (2012). POU5F1-directed silencing of the CGA subunit gene of human chorionic gonadotropin in human choriocarcinoma and embryonic stem cells through squelching of the transactivational properties of ETS2. Molecular Endocrinology 26: 859-872. PMID: 22446105

Roberts, R.M., Katayama, M., Magnuson, S.R., Falduto, M.T., and Torres, K.E. (2011). Transcription profiling of individual twin blastomeres derived by splitting two-cell stage murine embryos. Biology of Reproduction 84(3): 387-94. PMID: 21076082

Roberts, R.M. and Fisher, S.J. (2011). Trophoblast Stem Cells. Biology of Reproduction 84(3): 412-21. PMID: 21106963

Schulz, L.C. and Roberts, R.M. (2011). Dynamic changes in leptin distribution in the progression from ovum to blastocyst of the pre-implantation mouse embryo. Reproduction 141(6): 767-77. PMID: 21444625

Zhou, L., Wang, W., Liu, Y., de Castro, J.F., Ezashi, T.E., Telugu, B.P., Roberts, R.M., Kaplan, H.J., and Dean, D.C. (2011). Differentiation of induced pluripotent stem cells of swine into rod photoreceptors and their integration into the retina. Stem Cells 29(6): 972-80.
PMID: 21491544

Ezashi, T.E., Matsuyama, H., Telugu, B.P., Roberts, R.M. (2011). Generation of colonies of induced trophoblast cells during standard reprogramming of porcine fibroblasts to induced pluripotent stem cells. Biol Reprod 85(4): 779-87. PMID: 21734265

Telugu, B.P., Ezashi, T., Sinha, S., Alexenko, A., Spate, L., Prather, R.S. and Roberts R.M. (2011). LIF-dependent, pluripotent stem cells established from inner cell mass of porcine embryos. J. Biol. Chem. 286(33): 28948-53. PMID 21705331

Jašarević, E., Sieli, P.T., Twellman, E.E., Welsh, T.H., Schachtman, T.R., Roberts, R.M., Geary, D.C., Rosenfeld, C.S. (2011). Disruption of adult expression of sexually selected traits by developmental exposure to bisphenol A. PNAS USA 108(28): 11715-20. PMID: 21709224

Katayama, M. and Roberts, R.M. (2010). The effect of superovulation on the contributions of individual blastomeres from 2-cell stage CF1 mouse embryos to the blastocyst. The International Journal of Developmental Biology 54(4): 675-81. PMID 20209440

Katayama, M., Ellersieck, M., and Roberts, R.M. (2010). Development of monozygotic twin mouse embryos from the time of blastomere separation at the two-cell stage to blastocyst. Biology of Reproduction 82(6): 1237-47. PMID 20181620

Telugu, B.P., Ezashi, T.E., and Roberts, R.M. (2010). Porcine Induced Pluripotent Stem Cells Analogous to Naïve and Primed Embryonic Stem Cells of the Mouse. The International Journal of Developmental Biology 54(11-12): 1703-11 (Special issue on Animal Cloning and Cell Reprogramming). PMID 21305472

Telugu, B.P., Ezashi, T.E., and Roberts, R.M. (2010). The Promise of Stem Cell Research in Pigs and Other Ungulate Species. Stem Cell Review 6(1): 31-41. PMID 19949895

Schulz, L.C, Widmaier, E.P, Qiu, J, and Roberts, R.M. (2009). Effect of leptin on mouse trophoblast giant cells. Biology of Reproduction 80(3): 415-24. PMID 19038858

Egen, T.E., Ealy, A.D., Landon, L.A., Roberts, R.M., and Green, J.A. (2009). Autoimmunization of ewes against pregnancy-associated glycoproteins does not interfere with the establishment and maintenance of pregnancy. Animal 3(6): 850-7. PMID 22444772

Walker, A., Kimura, K., and Roberts, R.M. (2009). Expression of bovine interferon-tau variants according to sex and age of conceptuses. Theriogenology 72(1): 44-53. PMID 19324401

Walker, A. and Roberts, R.M. (2009). Characterization of the bovine type I IFN Locus: Rearrangements, expansions, and novel subfamilies. BMC Genomics 10:187-202. PMID 19393062

Ezashi, T., Telugu, B., Alexenko, A., Shrikesh S., Sinha, S., and Roberts, R.M. (2009). Derivation of induced pluripotent stem cells from pig somatic cells. Proceedings of the National Academy of Sciences USA 106(27): 10993-8. PMID 19541600

Tanasijevic, B., Dai, B., Ezashi, T., Livingston, K., Roberts, R.M., and Rasmussen, T.P. (2009). Progressive accumulation of epigenetic heterogeneity during human ES cell culture. Epigenetics 4(5): 330-8. PMID 19571681

Roberts, R.M., Telugu, B.P.L, and Ezashi, T. (2009). Induced pluripotent stem cells from swine (Sus scrofa): why they may prove to be important. Cell Cycle 8(19): 3078-81. PMID 19738434

Roberts, R.M. (2008). Interferon-Tau, a Type 1 Interferon involved in maternal recognition of pregnancy. Cytokine and Growth Factor Review. 18(5-6): 403-8. PMC 2000448 PMID 17662642

Fountain, E.D., Mao, J., Whyte, J.J., Mueller, K.E., Ellersieck, M.R., Will, M.R., Roberts, R.M., MacDonald, R., and Rosenfeld, C.S. (2008). Effects of diets enriched in omega-3 and omega-6 polyunsaturated fatty acids on offspring sex-ratio and maternal behavior in mice. Biology of Reproduction 78(2): 211-7. PMID 17928632

Das, P., Ezashi, T.E., Gupta, R., and Roberts, R.M. (2008). Combinatorial roles of protein kinase A, Ets2 and CBP/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line. Molecular Endocrinology 22(2): 331-43. PMID 17975022

Schulz, L.C., Ezashi, T.E., Das, P., Westfall, S.D., Livingston, K.A., and Roberts, R.M. (2008). Human embryonic stem cells as models for trophoblast differentiation. Placenta 29 Supplement A (Trophoblast Research): S10-6. PMC 2330081 PMID 18054384

Roberts, R.M., Chen, Y., Ezashi, T.E., and Walker, A. (2008). Interferons and the Maternal-Conceptus Dialog in Mammals. Seminars in Cell and Developmental Biology 19(2):170-7. PMC2278044 PMID 198032074

Das, P., Ezashi, T., Schulz, L.C., Westfall, S.D., Livingston, K.A., and Roberts, R.M. (2008). Effects of FGF2 and Oxygen in BMP4-Driven differentiation of trophoblast from human embryonic stem cells. Stem Cell Research 1(1):61-74. PMC 2634289 PMID 19194525

Ezashi, T., Das, P., Gupta, R., Walker, A., and Roberts, R.M. (2008). The Role of Homeobox Protein Distal-less3 and its interaction with Ets2 in Regulating Interferon-Tau Gene Expression-Synergistic transcriptional activation with Ets2. Biology of Reproduction 79(1):115-24.
PMID 18322277

Westfall, S.D., Sachdev, S., Das, P., Hearne, L., Hannink, M., Roberts, R.M., and Ezashi, T.E. (2008). Identification of Oxygen Sensitive Transcriptional Programs in Human Embryonic Stem Cell. Stem Cells and Development 17(5):869-81. PMID 18811242

Ghosh, D., Srivastava, G., Xu, D., and Roberts, R.M. (2008). A link between SIN1 (MAPKAP1) and Poly(rC) Binding protein-2 (PCBP2) in counteracting environmental stress. Proceedings of the National Academy of Sciences USA 105(33):11673-8. PMID 18687895

Green, M.P., Spate, L.D., Parks, T.E., Kimura, K., Murphy, C.N., Williams, J.E., Kerley, M.S., Green, J.A., Keisler, D.H., and Roberts, R.M. (2008). Nutritional skewing of conceptus sex in sheep: Effects of a maternal diet enriched in rumen-protected polyunsaturated fatty acids (PUFA). Reproductive Biology and Endocrinology 6: 21. PMID 18541015

Chen, Y., Antoniou, E., Liu, Z., Hearne, L., and Roberts, R.M. (2007). A Microarray analysis for genes regulated by interferon-tau in Ovine luminal epithelial cells. Reproduction 134(1): 123-35. PMID 17641094

Whyte, J.J., Roberts R.M., and Rosenfeld, C.S. (2007). Fluorescent in situ hybridization for sex chromosome determination before and after fertilization in mice. Theriogenology 67(5): 1022-31. PMID 17215034

Chakrabarty, A. and Roberts, R.M. (2007). Ets-2 and C/EBP-beta are important mediators of ovine trophoblast Kunitz domain protein-1 gene expression in trophoblast. BMC Molecular Biology 8:14. PMC1817651 PMID 17326832

Alexenko, A., Mao, J., Ellersieck, M., Davis, A., Whyte, J.J., Rosenfeld, C.S., and Roberts R.M. (2007). The contrasting effects of ad libitum and restricted feeding of a diet very high in saturated fats on sex ratio and metabolic hormones in mice. Biology of Reproduction 77(4): 599-604. PMID 17522073

Chen, Y., Green, J.A., Antoniou, E., Ealy, A.E., Mathialagan, N.P., Walker, A.M., Avalle, M.P., Rosenfeld, C.S., Hearne, L., and Roberts, R.M. (2006). Effect of Interferon-tau Administration on Endometrium of Nonpregnant Ewes: A Comparison with Pregnant Ewes. Endocrinology 147(5): 2127-37. PMID 16469802

Chakrabarty, A., Green J.A., and Roberts, R.M. (2006). Origin and evolution of the TKDP gene family. Gene 373: 35-43. PMID 16567063

Chakrabarty, A., MacLean, J., Roberts, R.M., Hughes, A., and Green, J.A. (2006). Rapid Evolution of the trophoblast Kunitz domain proteins (TKDPs) – a multi-gene family expressed in the trophoblast of ruminants. Journal of Molecular Evolution 63(2): 274-82. PMID 16830095

Roberts, R.M., Yong, H.J., and Smith, S. (2006). What Drives the Formation of Trophectoderm During Early Embryonic Development? Journal of Reproduction and Development 52 Supplement: S87-S97. [link to article]

Ezashi, T., Das, P., and Roberts, R.M. (2006). Regulation of IFN-tau gene expression by uterine factors: interaction between the conceptus and maternal environment during early pregnancy in cattle and sheep. Journal of Reproduction and Development 52 Supplement: S99-109. [link to article]

Green, J.A. and Roberts, R.M. (2006). Establishment of an ELISA for the detection of native bovine pregnancy-associated glycoprotein secreted by trophoblast binucleate cells. Methods in Molecular Medicine 122: 321-30. PMID 16511990

Earlier Publications (1966-2005) are readily accessible via PubMed with a few exceptions.

Dr. Roberts’ full CV is available upon request.

Publication list last updated May 2018


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